More than 40 people have been killed in the latest Israeli strikes across the Strip, according to hospital sources.
There are reports that at least 36 bodies were taken to hospitals in the south, which saw intense Israeli bombardment overnight.
On a single day this week, two hospitals in Gaza were hit by Israeli strikes, according to hospitals and first responders.
Israeli warplanes dropped six bombs simultaneously at the European Hospital in Khan Younis, killing 28 people and injuring dozens, the Hamas-run civil defence agency said.
Dr Tom Potokar, a plastic surgeon who was working with the Ideals international aid charity in the hospital, said the explosions had hit directly with “no warning whatsoever”.
The Israeli military said it had conducted a “precise strike” on “Hamas terrorists in a command and control centre” which it claimed was beneath the hospital.
In a statement, the Israeli military said Hamas “continues” to use hospitals in Gaza for its activities – a long-standing Israeli allegation which the group denies.
As Israel carries out strikes in southern Gaza, further north, it has issued one of the most sweeping evacuation orders for civilians yet seen in this war.
Large swathes of Gaza City, an area already partially destroyed by bombing, have been declared unsafe, the residents taking shelter there told to leave for their safety ahead of “intense strikes” by the Israel Defense Forces (IDF).
Among the buildings highlighted by Israel are the Islamic University, Al-Shifa Hospital, and three former schools.